ENMD-1068 (hydrochloride)

ENMD-1068 (hydrochloride)

• CAS Number: 2703451-51-6
• UNSPSC Description: ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 hydrochloride also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 hydrochloride can be used in the study of endometriosis and liver fibrosis[1][2].
• Target Antigen: Apoptosis; Protease Activated Receptor (PAR)
• Type: Reference compound
• Related Pathways: Apoptosis;GPCR/G Protein
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/enmd-1068-hydrochloride.html
• Purity: 98.33
• Solubility: DMSO : 200 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
• Smiles: O=C(N1CCN(C(CC(C)C)=O)CC1)CCCCCN.Cl
• Molecular Weight: 319.87
• References & Citations: [1]Sun Q, et al. ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice. Sci Rep. 2017 Jul 14;7(1):5498. doi: 10.1038/s41598-017-05190-7. Erratum in: Sci Rep. 2019 Dec 10;9(1):19125. |[2]Wang Y, et al. ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model. Am J Obstet Gynecol. 2014 Jun;210(6):531.e1-8.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported