Products for Research Use Only
RegisterLogin

Pretomanid-d4

CAT: 0804-HY-10844SSize: 500 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10844SSize:500 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Pretomanid-d4 is the deuterium labeled Pretomanid. Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB) . The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL[1][2].
CAS Number
1346617-34-2
UNSPSC
12352005
Target
Antibiotic; Bacterial; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Purity
99.83
Solubility
10 mM in DMSO|DMSO : 125mg/mL (ultrasonic)
Smiles
O=[N+](C1=CN2C(OC[C@H](C2([2H])[2H])OC([2H])([2H])C3=CC=C(C=C3)OC(F)(F)F)=N1)[O-]
Molecular Formula
C14H8D4F3N3O5
Molecular Weight
363.28
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Stover CK, et al. A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. Nature. 2000 Jun 22;405 (6789) :962-6.|[3]Lenaerts AJ, et al. Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models. Antimicrob Agents Chemother. 2005 Jun;49 (6) :2294-301.|[4]Manjunatha UH, et al. Mycobacterium leprae is naturally resistant to PA-824. Antimicrob Agents Chemother. 2006 Oct;50 (10) :3350-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-10844-01Pretomanid
HY-10844R-01Pretomanid (Standard)
HY-10844S1Pretomanid-d5
HY-151912S-01Picolinafen-d4 (4-Fluorophenyl-d4)
HY-132468SKeto Pioglitazone-d4 (M-III-d4)
HY-151892SGlimepiride-d4 (phenylethyl-α, α, β, β-d4) (cis/trans)
HY-151910S(±) -Fluoxetine-d4 Oxalate (trifluoromethylphen-d4-oxy)
HY-W654154Dexmedetomidine-d4 L-tartrate (-d4-major)
HY-113313S2Aldosterone-d4
HY-15731SEstetrol-d4

Alternative Products

CatalogName
AR-P32555-01Pretomanid-d4 (PA-824-d4)
TRC-P122502-2.5MG(S)-PA 824-d4 (Pretomanid-d4)
P142-50MGPretomanid
TRC-D466100-25MGDesnitro Pretomanid
CS-O-36051Pretomanid-d5
B3033-5Pretomanid (PA-824)
RM-P456011-01Pretomanid Impurity 11
RM-P456007-01Pretomanid Impurity 7
RM-P456006-01Pretomanid Impurity 6
RM-P456003-01Pretomanid Impurity 3

Popular Products