Phenacetin-d5

CAT: 0804-HY-B0476S-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0476S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Phenacetin-d5 is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[1][2][3].
CAS Number
[69323-74-6]
Product Name Alternative
Acetophenetidin-d5
UNSPSC
12352005
Hazard Statement
H302, H350
Target
COX
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Concentration
10mM
Purity
99.51
Solubility
DMSO : ≥ 100mg/mL|H2O : 0.67mg/mL (ultrasonic)
Smiles
CC(NC1=CC=C(C=C1)OC([2H])([2H])C([2H])([2H])[2H])=O
Molecular Formula
C10H8D5NO2
Molecular Weight
184.25
Precautions
H302, H350
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Chandrasekharan NV, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99 (21) :13926-31.|[3]Xiao-Meng He, et al. Effects of long-term smoking on the activity and mRNA expression of CYP isozymes in rats. J Thorac Dis. 2015 Oct; 7 (10) : 1725–1731.|[4]Na Gao, et al. Inhibition of Baicalin on Metabolism of Phenacetin, a Probe of CYP1A2, in Human Liver Microsomes and in Rats. PLoS One. 2014; 9 (2) : e89752.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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