Phenacetin-d5

• Description :

  Phenacetin-d5 is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[1][2][3].

• Product Name Alternative :

  Acetophenetidin-d5

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H350

• Target :

  COX

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Inflammation/Immunology

• Concentration :

  10mM

• Purity :

  99.51

• Solubility :

  DMSO : ≥ 100mg/mL|H2O : 0.67mg/mL (ultrasonic)

• Smiles :

  CC(NC1=CC=C(C=C1)OC([2H])([2H])C([2H])([2H])[2H])=O

• Molecular Formula :

  C10H8D5NO2

• Molecular Weight :

  184.25

• Precautions :

  H302, H350

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Chandrasekharan NV, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99 (21) :13926-31.|[3]Xiao-Meng He, et al. Effects of long-term smoking on the activity and mRNA expression of CYP isozymes in rats. J Thorac Dis. 2015 Oct; 7 (10) : 1725–1731.|[4]Na Gao, et al. Inhibition of Baicalin on Metabolism of Phenacetin, a Probe of CYP1A2, in Human Liver Microsomes and in Rats. PLoS One. 2014; 9 (2) : e89752.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [69323-74-6]