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Phenacetin

CAT: 0804-HY-B0476-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0476-01Size:500 mg
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Description
Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[1][2][3].
CAS Number
[62-44-2]
Product Name Alternative
Acetophenetidin
UNSPSC
12352005
Hazard Statement
H302, H350, H360
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/phenacetin.html
Purity
99.95
Solubility
DMSO : ≥ 100 mg/mL|H2O : 0.67 mg/mL (ultrasonic)
Smiles
CC(NC1=CC=C(OCC)C=C1)=O
Molecular Formula
C10H13NO2
Molecular Weight
179.22
Precautions
H302, H350, H360
References & Citations
[2]Xiao-Meng He, et al. Effects of long-term smoking on the activity and mRNA expression of CYP isozymes in rats. J Thorac Dis. 2015 Oct; 7 (10) : 1725–1731.|[3]Na Gao, et al. Inhibition of Baicalin on Metabolism of Phenacetin, a Probe of CYP1A2, in Human Liver Microsomes and in Rats. PLoS One. 2014; 9 (2) : e89752.|[1]Chandrasekharan NV, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99 (21) :13926-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-3

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