Phenacetin

• Description:

  Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[1][2][3].

• Product Name Alternative:

  Acetophenetidin

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H350, H360

• Target:

  COX

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/phenacetin.html

• Purity:

  99.95

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : 0.67 mg/mL (ultrasonic)

• Smiles:

  CC(NC1=CC=C(OCC)C=C1)=O

• Molecular Formula:

  C10H13NO2

• Molecular Weight:

  179.22

• Precautions:

  H302, H350, H360

• References & Citations:

  [2]Xiao-Meng He, et al. Effects of long-term smoking on the activity and mRNA expression of CYP isozymes in rats. J Thorac Dis. 2015 Oct; 7 (10) : 1725–1731.|[3]Na Gao, et al. Inhibition of Baicalin on Metabolism of Phenacetin, a Probe of CYP1A2, in Human Liver Microsomes and in Rats. PLoS One. 2014; 9 (2) : e89752.|[1]Chandrasekharan NV, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99 (21) :13926-31.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  COX-3

• CAS Number:

  [62-44-2]