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Salmeterol-d5

CAT: 0804-HY-14302S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14302S1Size:1 mg
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Description
Salmeterol-d5 is a deuterated labeled Salmeterol[1]. Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[2].
CAS Number
1093433-84-1
Product Name Alternative
GR33343X-d5
UNSPSC
12352005
Target
Adrenergic Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Endocrinology
Smiles
[2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1CCCCOCCCCCCNCC(C2=CC(CO)=C(C=C2)O)O
Molecular Formula
C25H32D5NO4
Molecular Weight
420.60
References & Citations
[1]Malcolm Johnson. Effects of beta2-agonists on resident and infiltrating inflammatory cells. J Allergy Clin Immunol. 2002 Dec;110 (6 Suppl) :S282-90.|[2]Panayiotis A Procopiou, et al. The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group. Bioorg Med Chem. 2011 Oct 15;19 (20) :6026-32.|[3]Zhiyuan Wang, et al. Efficacy of salmeterol and formoterol combination treatment in mice with chronic obstructive pulmonary disease. Exp Ther Med. 2018 Feb;15 (2) :1538-1545.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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