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Synucleozid (hydrochloride)

CAT: 0804-HY-135902A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135902A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Synucleozid hydrochloride (NSC 377363 hydrochloride) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein. Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson’s disease[1].
CAS Number
2741856-68-6
Product Name Alternative
NSC 377363 (hydrochloride)
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/synucleozid-hydrochloride.html
Concentration
10mM
Purity
98.23
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)
Smiles
N=C(C1=CC2=C(C=C1)C=C(C3=CC=C(NC4=CC=C(C(N)=N)C=C4)C=C3)N2)N.Cl
Molecular Formula
C22H21ClN6
Molecular Weight
404.90
References & Citations
[1]Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117 (3) :1457-1467.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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