Products for Research Use Only
RegisterLogin

Synucleozid-2.0

CAT: 0804-HY-401209-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-401209-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Synucleozid-2.0 is a small-molecule inhibitor targeting the iron-responsive element (IRE) structure in the 5' untranslated region (5'UTR) of SNCA mRNA. Synucleozid-2.0 inhibits ribosome assembly onto SNCA mRNA and selectively reduces α-synuclein protein translation. Synucleozid-2.0 is promising for research of Parkinson's disease (PD) and related α-synucleinopathies[1].
CAS Number
613226-91-8
UNSPSC
12352005
Target
DNA/RNA Synthesis; α-synuclein
Related Pathways
Cell Cycle/DNA Damage; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(NC1=CC2=C(C=C1)C=NN2)CSC3=NN=C(N3C4=CC=C(C=C4)Br)C5=CC=NC=C5
Molecular Formula
C22H16BrN7OS
Molecular Weight
506.38
References & Citations
[1]Tong Y, et al. Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera. Proc Natl Acad Sci U S A. 2024 Jan 9;121 (2) :e2306682120.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-135902Synucleozid
HY-135902A-01Synucleozid (hydrochloride)
HY-W110794-01Crystal violet, IND (0.0-2.0)
HY-154918-01LysoPE (18:2/0:0)
HY-118050L589420-0-2
HY-172552RECTAS-2.0
HY-145520-01(±) -2'-hydroxy Ceramide (d18:0/18:0)
HY-175088EOP (t18:0/30:0/18:2)
HY-163165S16:0-19:2-16:0 TG-d5
HY-165657SEOP (t18:0/28:0/18:2) -d11

Alternative Products

CatalogName
GTR19240941-01Synucleozid-2.0
GTR19204705-01Synucleozid
MBS5753988Synucleozid hydrochloride
OR22161Tricyclo[3.2.0.0~2,7~]heptane
RRSP525-DLight Green 0.2% in 0.2% Acetic Acid
T206725-01RECTAS-2.0
T36671C2 Phytoceramide (t18:0/2:0)
1216736Biosan, Rotor Type R-2/0.5/0.2
E4966000010Varispenser 2 - 0.2 - 2 mL
E1151112 Place Rotor For 0.2, 0.5, 1.5 & 2.0 mL - ABDOS

Popular Products