APE1-IN-1
CAT:
804-HY-136731-05
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
APE1-IN-1
- CAS Number: 524708-03-0
- UNSPSC Description: APE1-IN-1 is a potent and blood-brain barrier (BBB) penetrant apurinic/apyrimidinic (AP) endonuclease 1 (APE1) inhibitor with an IC50 value of 2 μM. APE1-IN-1 can potentiate the cytotoxicity of the alkylating agents Methylmethane sulfonate and Temozolomide (HY-17364) to cancer cells[1].
- Target Antigen: DNA/RNA Synthesis
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/ape1-in-1.html
- Smiles: CC(NC(S1)=C(C2=NC3=CC=CC=C3S2)C4=C1CN(C(C)C)CC4)=O
- Molecular Weight: 371.531
- References & Citations: [1]Rai G, et al. Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors. J Med Chem. 2012 Apr 12;55(7):3101-12.
- Shipping Conditions: Room Temperature