APE1-IN-1

CAT: 0804-HY-136731-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-136731-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
APE1-IN-1 is a potent and blood-brain barrier (BBB) penetrant apurinic/apyrimidinic (AP) endonuclease 1 (APE1) inhibitor with an IC50 value of 2 μM. APE1-IN-1 can potentiate the cytotoxicity of the alkylating agents Methylmethane sulfonate and Temozolomide (HY-17364) to cancer cells[1].
CAS Number
[524708-03-0]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ape1-in-1.html
Purity
99.52
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(NC(S1)=C(C2=NC3=CC=CC=C3S2)C4=C1CN(C(C)C)CC4)=O
Molecular Formula
C19H21N3OS2
Molecular Weight
371.53
References & Citations
[1]Rai G, et al. Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors. J Med Chem. 2012 Apr 12;55 (7) :3101-12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-151883-01APE1-IN-2
HY-149442APE1-IN-3
HY-P82375-01APE1 Antibody (YA2120, Rabbit)
HY-P84226-01APE1 Antibody (YA3923, Mouse)
HY-N6838-011,1,1,1-Kestohexaose
HY-1336231,1,1-Tribromoacetone
HY-157129AMPK-α1β1γ1 activator 1
HY-W160628S1,1,1-Trimethoxypropane-d5
HY-149536TWIK-1/TREK-1-IN-1
HY-1336291,1,1,3-Tetrachloroacetone

Alternative Products

CatalogName
BA3980-5APE1-IN-1
E8ER1802-49APE1
MBS855868-01APE1 Antibody
LF-PA0242anti-APE1

Popular Products