APE1-IN-1

• UNSPSC Description:

  APE1-IN-1 is a potent and blood-brain barrier (BBB) penetrant apurinic/apyrimidinic (AP) endonuclease 1 (APE1) inhibitor with an IC50 value of 2 μM. APE1-IN-1 can potentiate the cytotoxicity of the alkylating agents Methylmethane sulfonate and Temozolomide (HY-17364) to cancer cells[1].

• Target Antigen:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ape1-in-1.html

• Smiles:

  CC(NC(S1)=C(C2=NC3=CC=CC=C3S2)C4=C1CN(C(C)C)CC4)=O

• Molecular Weight:

  371.531

• References & Citations:

  [1]Rai G, et al. Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors. J Med Chem. 2012 Apr 12;55(7):3101-12.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  524708-03-0