Products for Research Use Only
RegisterLogin

APE1-IN-2

CAT: 0804-HY-151883-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-151883-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
APE1-IN-2 (compound AP1) is a Pt (IV) proagent, targeting a critical BER protein, apurinic/apyrimidinic endonuclease 1 (APE1) . APE1-IN-2 shows anticancer activity. APE1-IN-2 induces intracellular accumulation of platinum and activates DNA damage response and apoptosis signals[1].
CAS Number
2923433-95-6
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ape1-in-2.html
Purity
98.28
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[Pt](Cl)(Cl)(OC(C1=CC2=CC=CC([N+]([O-])=O)=C2N1)=O)([NH3])[NH3]
Molecular Formula
C9H12Cl2N4O5Pt
Molecular Weight
522.21
References & Citations
[1]Yuan Y, et al. Pt (IV) Prodrug as a Potential Antitumor Agent with APE1 Inhibitory Activity. J Med Chem. 2022 Nov 24;65 (22) :15344-15357.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-149442APE1-IN-3
HY-136731-01APE1-IN-1
HY-P84226-01APE1 Antibody (YA3923, Mouse)
HY-P82375-01APE1 Antibody (YA2120, Rabbit)
HY-W011060-01Cryptand 2.2.2
HY-B1500-012,2,2-Trichloroethanol
HY-W0733142,2,2-Trifluoroethoxyamine (hydrochloride)
HY-N2048-012,2':5',2''-Terthiophene
HY-132268-01Cav 2.2 blocker 2
HY-B1500R-012,2,2-Trichloroethanol (Standard)

Alternative Products

CatalogName
T73299-01APE1-IN-2
MBS8576929-01APE1
BA3980-50APE1-IN-1
GWB-979FBAAPE1 Antibody
GTR19237544-01APE1-IN-3

Popular Products