TP-064

TP-064

• Product Name Alternative: 1-hydroxycholecalciferol-d7; 1.alpha.-Hydroxyvitamin D3-d7
• CAS Number: 2080306-20-1
• UNSPSC Description: TP-064 is a potent and selective proteinarginine methyltransferase 4 (PRMT4; CARM1) inhibitor (IC50 IC50 of 340 nM) and MED12 (IC50 of 43 nM). TP-064 is inactive against the other family members except for PRMT6 (IC50 of 1.3 μM). TP-064 has anticancer activities[1].
• Target Antigen: Histone Methyltransferase
• Type: Reference compound
• Related Pathways: Epigenetics
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/tp-064.html
• Purity: 99.61
• Solubility: DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : ≥ 50 mg/mL
• Smiles: O=C(C1=CC=CC(OC2=CC=CC=C2)=C1)N(CC3=CC(C4CCN(CC4)CCNC)=NC=C3)C
• Molecular Weight: 458.60
• References & Citations: [1]Kazuhide Nakayama, et al. TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. Oncotarget. 2018 Apr 6;9(26):18480-18493.|[2]Yiheng Zhang, et al. PRMT4 inhibitor TP-064 inhibits the pro-inflammatory macrophage lipopolysaccharide response in vitro and ex vivo and induces peritonitis-associated neutrophilia in vivo. Biochim Biophys Acta Mol Basis Dis. 2021 Jul 24;1867(11):166212.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported