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DTNA rabbit pAb

CAT: 0855-ES16885-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES16885-01Size:50 µL
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Background
The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],
UniProt
Q9Y4J8
Swiss Prot
Q9Y4J8
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human DTNA AA range: 131-181
Target
DTNA
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm. Cell junction, synapse. Cell membrane . In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane. .
Gene ID (Human)
1837

UniProtKB · Q9Y4J8

Dystrobrevin alpha

DTNA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y4J8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DTNA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
DTN-A
EC number
—
Processing
—
Secondary accessions
A8K541, A8MSZ0, A8MUY4, B4DGS6, B4DIR0, B4DIU8, M0QYX6, M0R397, O15332, O15333, O75697, Q13197, Q13198, Q13199, Q13498, Q13499, Q13500, Q59GK7, Q9BS59
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Cardiomyopathy

Cellular component

Cell membraneCytoplasmMembraneSynapse

Domain

Coiled coilZinc-finger

Ligand

Metal-bindingZinc

PTM

Phosphoprotein

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