Products for Research Use Only
RegisterLogin

Tianeptine-d12

CAT: 0804-HY-90003SSize: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-90003SSize:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Tianeptine-d12 is a deuterated analog of Tianeptine.Tianeptine is an atypical antidepressant. Tianeptine is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR). Tianeptine is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. Tianeptine increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects.
CAS Number
1189870-26-5
UNSPSC
12352005
Target
Akt; iGluR; Isotope-Labeled Compounds; MMP; NF-κB; Opioid Receptor; PI3K
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others; PI3K/Akt/mTOR
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Solubility
10 mM in DMSO
Smiles
N(C(C(C(C(C(C(C(O)=O)([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])C1C=2C(S(=O)(=O)N(C)C=3C1=CC=CC3)=CC(Cl)=CC2
Molecular Formula
C21H13D12ClN2O4S
Molecular Weight
449.03
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Wagstaff A J, et al. Tianeptine: a review of its use in depressive disorders[J]. CNS drugs, 2001, 15: 231-259.|[3]Plaisant F, et al. Neuroprotective properties of tianeptine: interactions with cytokines[J]. Neuropharmacology, 2003, 44 (6) : 801-809.|[4]Sharma A K, et al. Effects of calcium channel blocker, nifedipine, on antidepressant activity of fluvoxamine, venlafaxine and tianeptine in mice[J]. Int J Basic Clin Pharmacol, 2015, 4: 1-7.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Chemical Information

Tianeptine-d12
CAS Number1189870-26-5
PubChem CID46783083
IUPAC Name7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]-2,2,3,3,4,4,5,5,6,6,7,7-dodecadeuterioheptanoic acid
Molecular FormulaC21H25ClN2O4S
Molecular Weight449.0
XLogP1.2
Topological Polar Surface Area95.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Heavy Atom Count29
Formal Charge0
Complexity654
SMILES
[2H]C([2H])(C(=O)O)C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])NC1C2=C(C=C(C=C2)Cl)S(=O)(=O)N(C3=CC=CC=C13)C
InChI
InChI=1S/C21H25ClN2O4S/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26)/i2D2,3D2,4D2,7D2,10D2,13D2
InChIKey
JICJBGPOMZQUBB-WUQUEXLQSA-N
Chemical Structure
2D Structure
2D structure of Tianeptine-d12
CAS: 1189870-26-5
CID: 46783083
Formula: C21H25ClN2O4S
MW: 449.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight449.0
XLogP31.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Exact Mass448.1976771
Monoisotopic Mass448.1976771
Topological Polar Surface Area95.1 Ų
Heavy Atom Count29
Formal Charge0
Complexity654
Isotope Atom Count12
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-90003-01Tianeptine
HY-144224S-01Tianeptine-d6 (hydrochloride)
HY-90003A-01Tianeptine (sodium salt)
HY-W090294S-01Perylene-d12
HY-N0264S1Ligustrazine-d12
HY-W011416S-01Coronene-d12
HY-14274SAnastrozole-d12
HY-B1120STemephos-d12
HY-W017708S-01Triphenylene-d12
HY-121107S-01Chrysene-d12

Alternative Products

CatalogName
TRC-T436802-0.5MGTianeptine-d12
CS-T-103797(R) -Tianeptine- d12
TRC-T436826-25MG(R)-Tianeptine- d12
CS-T-103798(S) -Tianeptine- d12
TRC-T436836-25MG(S)-Tianeptine- d12
TRC-D221602-10MGDecarboxy Tianeptine-d12 Nitrile
sc-220251Tianeptine-d12 Methyl Ester
021841Tianeptine-d12 Methyl Ester discontinued
007618Decarboxy Tianeptine-d12 Nitrile discontinued
TRC-H281502-10MGN-Heptanoic Acid Tianeptine Disodium Salt-d12

Popular Products