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Tianeptine

CAT: 0804-HY-90003-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-90003-01Size:5 mg
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Description
Tianeptine is an atypical antidepressant. Tianeptine is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR) . Tianeptine is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. tianeptine increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects[1][2][3][4][5].
CAS Number
72797-41-2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Akt; iGluR; MMP; NF-κB; Opioid Receptor; PI3K
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Tianeptine.html
Purity
99.84
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C(CCCCCCNC(C1=CC=CC=C1N2C)C3=CC=C(C=C3S2(=O)=O)Cl)O
Molecular Formula
C21H25ClN2O4S
Molecular Weight
436.95
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Broqua P; Baudrie V; Chaouloff F Differential effects of the novel antidepressant tianeptine on L-5-hydroxytryptophan (5-HTP) -elicited corticosterone release and body weight loss. Eur Neuropsychopharmacol. 1992 Jun;2 (2) :115-20.|[2]Alamo C, et, al. Tianeptine, an atypical pharmacological approach to depression. Rev Psiquiatr Salud Ment. Jul-Sep 2019;12 (3) :170-186.|[3]Uzbay IT, et, al. Analgesic effect of tianeptine in mice. Life Sci. 1999;64 (15) :1313-9.|[4]Plaisant F, et, al. Neuroprotective properties of tianeptine: interactions with cytokines. Neuropharmacology. 2003 May;44 (6) :801-9.|[5]Jayasooriya RG, et al. Tianeptine sodium salt suppresses TNF-α-induced expression of matrix metalloproteinase-9 in human carcinoma cells via suppression of the PI3K/Akt-mediated NF-κB pathway. Environ Toxicol Pharmacol. 2014 Sep;38 (2) :502-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Akt; MMP-9; NF-κB; PI3K; δ Opioid Receptor/DOR; μ Opioid Receptor/MOR

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