AZD2098

• Description :

  AZD2098 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC50s of 7.8, 8.0, 8.0 and 7.6 for human, rat, mouse and dog respectively, used for asthma research[1][2].

• CAS Number :

  [566203-88-1]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  CCR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/AZD2098.html

• Purity :

  99.91

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |Ethanol : 5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=CN=C2OC)=O

• Molecular Formula :

  C11H9Cl2N3O3S

• Molecular Weight :

  334.18

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kindon N, et al. Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists. ACS Med Chem Lett. 2017 Sep 1;8 (9) :981-986.|[2]Asher Mullard. Cancer charity sees success re-prioritizing industry's shelved compounds. Nat Rev Drug Discov. 2014 May;13 (5) :319-21.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CCR4