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AZD0095

CAT: 0804-HY-148517-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-148517-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD0095 is a selective and orally active MCT4 inhibitor (IC50: 1.3 nM) . AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib (HY-10205) [1].
CAS Number
[2750001-23-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Monocarboxylate Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azd0095.html
Purity
99.42
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
CC1=C(O[C@H]2CN(C3=CC=C(C4=NN=C(CN5CCOCC5)C=C4)C=C3)CC2)C(C)=NC6=NC(C)=NN16
Molecular Formula
C27H32N8O2
Molecular Weight
500.60
Precautions
H315, H319, H335
References & Citations
[1]Goldberg FW, et al. Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology. J Med Chem. 2022 Dec 16.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MCT4

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