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AZD1208 (hydrochloride)

CAT: 0804-HY-15604ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-15604ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD1208 hydrochloride is an orally bioavailable, highly selective PIM kinases inhibitor[1].
CAS Number
1621866-96-3
UNSPSC
12352005
Target
Apoptosis; Autophagy; Pim
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; JAK/STAT Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZD1208_hydrochloride.html
Solubility
DMSO : 83.3 mg/mL (ultrasonic; warming)
Smiles
O=C(NC/1=O)SC1=C/C2=C(N3C[C@H](N)CCC3)C(C4=CC=CC=C4)=CC=C2.[H]Cl
Molecular Formula
C21H22ClN3O2S
Molecular Weight
415.94
References & Citations
[1]Dakin LA, et al. Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg Med Chem Lett. 2012 Jul 15;22 (14) :4599-604.|[2]Kreuz S, et al. Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas. Mol Cancer. 2015 Dec 8;14:205.|[3]Harada M, et al. The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. Oncotarget. 2015 Nov 10;6 (35) :37930-47.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PIM2

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