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H3B-8800

CAT: 0804-HY-111517-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111517-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
H3B-8800 is a potent and orally active SF3B splicing modulator. H3B-8800 direct interaction with the SF3b complex and shows anti-cancer activity. H3B-8800 has the potential for the research of acute myeloid leukemia (AML) with SF3B1 mutant[1].
CAS Number
1825302-42-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; SF3B1
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/H3B-8800.html
Purity
98.85
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N1CCN(C)CC1)O[C@H]([C@](C)(O)CC[C@@H](O)C2)/C=C/[C@H](C)[C@H](OC2=O)/C(C)=C/C=C/[C@@H](C)C3=NC=CC=C3
Molecular Formula
C31H45N3O6
Molecular Weight
555.71
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Seiler M, et al. H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers. Nat Med. 2018 May;24 (4) :497-504.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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