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H3B-968

CAT: 0804-HY-149887-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-149887-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
H3B-968 is the ATP-competitive inhibitor of Werner syndrome protein (WRN) with an IC50 of about 10 nM[1].
CAS Number
2912294-90-5
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/h3b-968.html
Purity
98.22
Solubility
DMSO : ≥ 250 mg/mL
Smiles
O=C(CNS(=O)(C1=NC(C2=CC=C(OC(F)(F)F)C=C2)=CC(C(F)(F)F)=N1)=O)NC3=CC=C(CC)C=C3
Molecular Formula
C22H18F6N4O4S
Molecular Weight
548.46
References & Citations
[1]Parker MJ, et al. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay. Biochemistry. 2023 Jul 18;62 (14) :2147-2160.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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