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Adenosine dialdehyde

CAT: 0804-HY-123055-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123055-01Size:5 mg
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Description
Adenosine dialdehyde, a purine nucleoside analogue, is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM) [1]. Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research[1][2].
CAS Number
34240-05-6
UNSPSC
12352005
Hazard Statement
H370
Target
Nucleoside Antimetabolite/Analog; S-adenosylhomocysteine hydrolase (SAHH)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/adenosine-dialdehyde.html
Concentration
10mM
Purity
99.18
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=CC(OC(C=O)CO)N1C=NC2=C(N)N=CN=C12
Molecular Formula
C10H11N5O4
Molecular Weight
265.23
Precautions
H370
References & Citations
[1]G V Madhavan, et al. Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase. J Med Chem|[2]B Bostrom, et al. Inhibitory effect of adenosine dialdehyde on in situ murine neuroblastoma growth.Cancer Res. 1988 Nov 1;48 (21) :5933-6.|[3]V Ramakrishnan, et al. Adenosine dialdehyde and neplanocin A: Potent inhibitors of S-adenosylhomocysteine hydrolase in neuroblastoma N2a cells. Neurochem Int. 1987;10 (4) :423-31.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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