Zonisamide

CAT: 0804-HY-B0124-01Size: 200 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0124-01Size:200 mg
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Description
Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with Kis of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy[1][2][3][4].
CAS Number
[68291-97-4]
Product Name Alternative
AD 810; CI 912
UNSPSC
12352005
Hazard Statement
H302, H361
Target
Apoptosis; Carbonic Anhydrase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/zonisamide.html
Purity
99.94
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 0.67 mg/mL (ultrasonic)
Smiles
O=S(CC1=NOC2=C1C=CC=C2)(N)=O
Molecular Formula
C8H8N2O3S
Molecular Weight
212.23
Precautions
H302, H361
References & Citations
[1]Kawajiri S, et al. Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD. Neurosci Lett. 2010 Sep 6;481 (2) :88-91. |[2]Ueda Y, et al. Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures. Brain Res Mol Brain Res. 2003 Aug 19;116 (1-2) :1-6. |[3]Wu Q, et al. Zonisamide alleviates cardiac hypertrophy in rats by increasing Hrd1 expression and inhibiting endoplasmic reticulum stress. Acta Pharmacol Sin. 2021 Oct;42 (10) :1587-1597.|[4]De Simone G, et al. Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies. Bioorg Med Chem Lett. 2005 May 2;15 (9) :2315-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CA II

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