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Zonisamide (sodium)

CAT: 0804-HY-B0124ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B0124ASize:1 Each
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Description
Zonisamide (AD 810) sodium is an orally active carbonic anhydrase inhibitor, with Kis of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide sodium exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide sodium also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide sodium can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy[1][2][3][4].
CAS Number
[68291-98-5]
Product Name Alternative
AD 810 sodium; CI 912 sodium
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Carbonic Anhydrase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Zonisamide-sodium.html
Solubility
10 mM in DMSO
Smiles
O=S(CC1=NOC2=C1C=CC=C2)([NH-])=O.[Na+]
Molecular Formula
C8H7N2NaO3S
Molecular Weight
234.21
Precautions
P264-P270-P330-P501
References & Citations
[1]Kawajiri S, et al. Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD. Neurosci Lett. 2010 Sep 6;481 (2) :88-91. |[2]Ueda Y, et al. Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures. Brain Res Mol Brain Res. 2003 Aug 19;116 (1-2) :1-6. |[3]Wu Q, et al. Zonisamide alleviates cardiac hypertrophy in rats by increasing Hrd1 expression and inhibiting endoplasmic reticulum stress. Acta Pharmacol Sin. 2021 Oct;42 (10) :1587-1597. |[4]De Simone G, et al. Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies. Bioorg Med Chem Lett. 2005 May 2;15 (9) :2315-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CA II

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