Zonisamide-d4

CAT: 0804-HY-B0124S-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0124S-01Size:1 mg
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Description
Zonisamide-d4 is the deuterium labeled Zonisamide. Zonisamide (AD 810) is an inhibitor of zinc enzyme carbonic anhydrase (CA), with Kis of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity. Zonisamide can be used for the rsearch for epilepsy, seizures and Parkinson's disease[1][2].
CAS Number
[1020720-04-0]
UNSPSC
12352005
Target
Calcium Channel; Carbonic Anhydrase; Isotope-Labeled Compounds; Sodium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.38
Solubility
DMSO : 250mg/mL (ultrasonic) |H2O : 0.67mg/mL (ultrasonic)
Smiles
C(S(N)(=O)=O)C=1C=2C(ON1)=C(C(=C(C2[2H])[2H])[2H])[2H]
Molecular Formula
C8H4D4N2O3S
Molecular Weight
216.25
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Peters DH, et al. Zonisamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy. Drugs. 1993 May;45 (5) :760-87.|[3]De Simone G, et al. Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies. Bioorg Med Chem Lett. 2005 May 2;15 (9) :2315-20.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
CA II

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