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8-Aminoadenosine

CAT: 0804-HY-125927-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-125927-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
8-Aminoadenosine (8-NH2-Ado), a RNA-directed nucleoside analogue, reduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine blocks Akt/mTOR signaling and induces autophagy and apoptosis in a p53-independent manner. 8-Aminoadenosine has antitumor activity[1][2][3].
CAS Number
3868-33-5
Product Name Alternative
8-NH2-Ado
UNSPSC
12352005
Hazard Statement
H301
Target
Akt; Apoptosis; Autophagy; DNA/RNA Synthesis; mTOR
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8-aminoadenosine.html
Purity
99.94
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2N)O[C@@H]1CO
Molecular Formula
C10H14N6O4
Molecular Weight
282.26
Precautions
H301
References & Citations
[1]Mala Shanmugam, et al. Targeting glucose consumption and autophagy in myeloma with the novel nucleoside analogue 8-aminoadenosine. J Biol Chem. 2009 Sep 25;284 (39) :26816-30.|[2]Jennifer Ann Frey, et al. 8-Amino-adenosine inhibits multiple mechanisms of transcription. Mol Cancer Ther. 2010 Jan;9 (1) :236-45.|[3]Alla Polotskaia, et al. 8-Amino-adenosine activates p53-independent cell death of metastatic breast cancers. Mol Cancer Ther. 2012 Nov;11 (11) :2495-504.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR

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