RN-18

CAT: 0804-HY-102014-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-102014-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

RN-18 is a HIV-1 viral infectivity factor (HIV-1 Vif) inhibitor with an IC50 of 6 μM in nonpermissive H9 cells.

CAS Number

431980-38-0

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/RN-18.html

Concentration

10mM

Purity

98.75

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC=C1OC)C2=CC=CC=C2SC3=CC=C([N+]([O-])=O)C=C3

Molecular Formula

C20H16N2O4S

Molecular Weight

380.42

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Mohammed I, et al. SAR and Lead Optimization of an HIV-1 Vif-APOBEC3G Axis Inhibitor. ACS Med Chem Lett. 2012 Jun 14;3 (6) :465-469.|[2]Nathans R, et al. Small-molecule inhibition of HIV-1 Vif. Nat Biotechnol. 2008 Oct;26 (10) :1187-92.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HIV-1

Chemical Information

2-(4-Nitrophenylthio)-N-(2-methoxyphenyl)benzamide

CAS Number	431980-38-0
PubChem CID	1317590
IUPAC Name	N-(2-methoxyphenyl)-2-(4-nitrophenyl)sulfanylbenzamide
Molecular Formula	C20H16N2O4S
Molecular Weight	380.4
XLogP	4.6
Topological Polar Surface Area	109
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Heavy Atom Count	27
Formal Charge	0
Complexity	505

SMILES

COC1=CC=CC=C1NC(=O)C2=CC=CC=C2SC3=CC=C(C=C3)[N+](=O)[O-]

InChI

InChI=1S/C20H16N2O4S/c1-26-18-8-4-3-7-17(18)21-20(23)16-6-2-5-9-19(16)27-15-12-10-14(11-13-15)22(24)25/h2-13H,1H3,(H,21,23)

InChIKey

JKNUDHUHXMELIJ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 431980-38-0

CID: 1317590

Formula: C20H16N2O4S

MW: 380.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	380.4
XLogP3	4.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	380.08307817
Monoisotopic Mass	380.08307817
Topological Polar Surface Area	109 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	505
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
BA1946-50	RN-18
A12980-25	RN-18 25mg
A12980-5	RN-18 5mg
A12980-10	RN-18 10mg
sc-101163	SMARCD3 (RN-18)
A12980-100	RN-18 100mg
A12980-50	RN-18 50mg
A12980-10mM-D	RN-18 10mM * 1mL in DMSO
sc-546777	SMARCD3 (RN-18) : m-IgG2a BP-HRP Bundle
BA7053-5	RN-9893

RN-18

Chemical Information

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