Coptisine (chloride) (Standard)

• UNSPSC Description:

  Coptisine (chloride) (Standard) is the analytical standard of Coptisine (chloride). This product is intended for research and analytical applications. Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC50 of 104.6 μg/mL and can be used for influenza A (H1N1) infection.

• Target Antigen:

  Bacterial; Indoleamine 2,3-Dioxygenase (IDO); Influenza Virus

• Type:

  Reference Standards

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Field of Research:

  Cancer; Infection; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/coptisine-chloride-standard.html

• Smiles:

  C1(C(CC[N+]2=C1C=C(C=C3)C(C4=C3OCO4)=C2)=C5)=CC6=C5OCO6.[Cl-]

• Molecular Weight:

  355.77

• References & Citations:

  [1]Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302.|[2]He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94.|[3]Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565.|[4]Zhou X, et al. Inhibition activity of a traditional Chinese herbal formula Huang-Lian-Jie-Du-Tang and its major components found in its plasma profile on neuraminidase-1. Sci Rep. 2017 Nov 14;7(1):15549.

• Shipping Conditions:

  Room temperature

• CAS Number:

  6020-18-4