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Coptisine (chloride) (Standard)

CAT: 0804-HY-N0736R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0736R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Coptisine (chloride) (Standard) is the analytical standard of Coptisine (chloride) . This product is intended for research and analytical applications. Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC50 of 104.6 μg/mL and can be used for influenza A (H1N1) infection.
CAS Number
6020-18-4
UNSPSC
12352005
Target
Bacterial; Indoleamine 2,3-Dioxygenase (IDO) ; Influenza Virus; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/coptisine-chloride-standard.html
Smiles
C1(C(CC[N+]2=C1C=C(C=C3)C(C4=C3OCO4)=C2)=C5)=CC6=C5OCO6.[Cl-]
Molecular Formula
C19H14ClNO4
Molecular Weight
355.77
References & Citations
[1]Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43 (1) :291-302.|[2]He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50 (2) :185-94.|[3]Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39 (3) :1010428317694565.|[4]Zhou X, et al. Inhibition activity of a traditional Chinese herbal formula Huang-Lian-Jie-Du-Tang and its major components found in its plasma profile on neuraminidase-1. Sci Rep. 2017 Nov 14;7 (1) :15549.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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