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Phellodendrine (chloride) (Standard)

CAT: 0804-HY-N0735RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N0735RSize:1 Each
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Description
Phellodendrine chloride (Standard) is the analytical standard of Phellodendrine chloride. Phellodendrine chloride is an orally active plant alkaloid. Phellodendrine chloride inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine chloride promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine chloride can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine chloride suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine chloride inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine chloride has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway.
CAS Number
104112-82-5
UNSPSC
12352005
Target
Akt; AMPK; Apoptosis; Autophagy; COX; Interleukin Related; MMP; mTOR; NF-κB; p38 MAPK; PI3K; PKC; Reactive Oxygen Species (ROS) ; Reference Standards; STAT
Type
Reference Standards
Related Pathways
Apoptosis; Autophagy; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Others; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/phellodendrine-chloride-standard.html
Smiles
C[N@@+]12CCC3=CC(OC)=C(O)C=C3[C@]1([H])CC4=CC(O)=C(OC)C=C4C2.[Cl-]
Molecular Formula
C20H24ClNO4
Molecular Weight
377.86
References & Citations
[1]Thu PM, et al. Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis. Eur J Pharmacol. 2019 May 5;850:23-34.|[2]Su S, Wang X, Xi X, et al. Phellodendrine promotes autophagy by regulating the AMPK/mTOR pathway and treats ulcerative colitis. J Cell Mol Med. 2021;25 (12) :5707-5720.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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