Phellodendrine (chloride) (Standard)

• UNSPSC Description:

  Phellodendrine (chloride) (Standard) is the analytical standard of Phellodendrine (chloride). This product is intended for research and analytical applications. Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis [1]. Phellodendrine chloride promotes autophagy by regulating the AMPK/mTOR pathway and reduce the intestinal damage of ulcerative colitis[2].

• Target Antigen:

  Autophagy

• Type:

  Reference Standards

• Related Pathways:

  Autophagy

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/phellodendrine-chloride-standard.html

• Smiles:

  C[N@@+]12CCC3=CC(OC)=C(O)C=C3[C@]1([H])CC4=CC(O)=C(OC)C=C4C2.[Cl-]

• Molecular Weight:

  377.86

• References & Citations:

  [1]Thu PM, et al. Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis. Eur J Pharmacol. 2019 May 5;850:23-34.|[2]Su S, Wang X, Xi X, et al. Phellodendrine promotes autophagy by regulating the AMPK/mTOR pathway and treats ulcerative colitis. J Cell Mol Med. 2021;25(12):5707-5720.

• Shipping Conditions:

  Room temperature

• CAS Number:

  104112-82-5