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Eprosartan-d3

CAT: 0804-HY-117743S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117743S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Eprosartan-d3 is the deuterium labeled Eprosartan. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively [1].
CAS Number
1185243-70-2
Product Name Alternative
MK-0364
UNSPSC
12352005
Target
Angiotensin Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Others
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
OC(/C(CC1=CC=CS1)=C/C2=CN=C(CCCC([2H])([2H])[2H])N2CC3=CC=C(C=C3)C(O)=O)=O
Molecular Formula
C23H21D3N2O4S
Molecular Weight
427.53
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]R M Edwards, et al. Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J Pharmacol Exp Ther. 1992 Jan;260 (1) :175-81.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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