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(S) -3,5-DHPG

CAT: 0804-HY-12598-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12598-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) -3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 μM and 3.9 μM for mGluR1a and mGluR5a, respectively[1]. (S) -3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia[2].
CAS Number
162870-29-3
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-3-5-dhpg.html
Concentration
10mM
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
O=C(O)[C@@H](N)C1=CC(O)=CC(O)=C1
Molecular Formula
C8H9NO4
Molecular Weight
183.16
Precautions
H302, H312, H332
References & Citations
[1]V Mutel, et al. Characterization of [ (3) H]Quisqualate Binding to Recombinant Rat Metabotropic Glutamate 1a and 5a Receptors and to Rat and Human Brain Sections. J Neurochem. 2000 Dec;75 (6) :2590-601.|[2]Agnieszka Nadlewska, et al. Effect of (S) -3,5-DHPG on Learning, Exploratory Activity and Anxiety in Rats With Experimental Hypoxia. Pol J Pharmacol. Jan-Feb 2002;54 (1) :11-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1; mGluR5

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