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INCA-6

CAT: 0804-HY-108544-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108544-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 specifically blocks targeting of NFAT (P) substrate to the calcineurin (CN) phosphatase site and is an effective inhibitor of CN-NFAT signaling[1][2][3].
CAS Number
3519-82-2
Product Name Alternative
Triptycene-1,4-quinone
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Nuclear Factor of activated T Cells (NFAT)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/inca-6.html
Concentration
10mM
Purity
98.02
Solubility
DMSO : 2.86 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C=CC(C2=C1C3C4=C(C2C5=C3C=CC=C5)C=CC=C4)=O
Molecular Formula
C20H12O2
Molecular Weight
284.31
Precautions
H315, H319, H320
References & Citations
[1]Ling Xiao, et al. Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes. Circ Res. 2008 Sep 26;103 (7) :733-42.|[2]Miho Shiratori, et al. P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways. J Neurochem. 2010 Aug;114 (3) :810-9.|[3]Anand Mohan Prasad, et al. Silencing calcineurin A subunit reduces SERCA2 expression in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2011 Jan;300 (1) :H173-80.|[4]Colin A Bretz, et al. The role of the NFAT signaling pathway in retinal neovascularization. Invest Ophthalmol Vis Sci. 2013 Oct 25;54 (10) :7020-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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