OSMI-1

• UNSPSC Description:

  OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans[1][2].

• Target Antigen:

  Acyltransferase; OGT

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Neuronal Signaling

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/osmi-1.html

• Purity:

  99.90

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(N(CC1=CC=CS1)CC2=CC=CO2)[C@H](NS(C3=CC(C=C4)=C(C=C3)NC4=O)(=O)=O)C5=CC=CC=C5OC

• Molecular Weight:

  563.64

• References & Citations:

  [1]Ortiz-Meoz RF, et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10(6):1392-7.|[2]Liu Y, et al. Discovery of a Low Toxicity O-GlcNAc Transferase (OGT) Inhibitor by Structure-based Virtual Screening of Natural Products. Sci Rep. 2017 Sep 26;7(1):12334.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1681056-61-0