OSMI-1

OSMI-1

• CAS Number: 1681056-61-0
• UNSPSC Description: OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans[1][2].
• Target Antigen: Acyltransferase; OGT
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Neuronal Signaling
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/osmi-1.html
• Purity: 99.90
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(N(CC1=CC=CS1)CC2=CC=CO2)[C@H](NS(C3=CC(C=C4)=C(C=C3)NC4=O)(=O)=O)C5=CC=CC=C5OC
• Molecular Weight: 563.64
• References & Citations: [1]Ortiz-Meoz RF, et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10(6):1392-7.|[2]Liu Y, et al. Discovery of a Low Toxicity O-GlcNAc Transferase (OGT) Inhibitor by Structure-based Virtual Screening of Natural Products. Sci Rep. 2017 Sep 26;7(1):12334.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported