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OSMI-2

CAT: 0804-HY-135784-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135784-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OSMI-2 (Compound 1b) is a cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-2 increases detained intron splicing in cells[1].
CAS Number
2260542-60-5
UNSPSC
12352005
Target
Acyltransferase; OGT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/osmi-2.html
Purity
98.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC)CN(C([C@@H](C1=CC=CC=C1OC)NS(=O)(C2=CC3=C(NC(C=C3)=O)C=C2)=O)=O)CC4=CC=CS4
Molecular Formula
C26H25N3O7S2
Molecular Weight
555.62
References & Citations
[1]Martin SES, et al. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 24;140 (42) :13542-13545.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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