OSMI-3

• UNSPSC Description:

  OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells[1].

• Target Antigen:

  Acyltransferase; OGT

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/osmi-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S(N[C@H](C1=CC=CC=C1OCCCC(OCC)=O)C(N(CC(OCC)=O)CC2=CC=CS2)=O)(C3=CC4=C(NC(C=C4)=O)C=C3)=O

• Molecular Weight:

  669.77

• References & Citations:

  [1]Martin SES, et al. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2260791-13-5