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OSMI-3

CAT: 0804-HY-135785-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135785-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells[1].
CAS Number
2260791-13-5
UNSPSC
12352005
Target
Acyltransferase; OGT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/osmi-3.html
Purity
99.08
Solubility
10 mM in DMSO
Smiles
O=S(N[C@H](C1=CC=CC=C1OCCCC(OCC)=O)C(N(CC(OCC)=O)CC2=CC=CS2)=O)(C3=CC4=C(NC(C=C4)=O)C=C3)=O
Molecular Formula
C32H35N3O9S2
Molecular Weight
669.77
References & Citations
[1]Martin SES, et al. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 24;140 (42) :13542-13545.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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