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AZD7254

CAT: 0804-HY-147744Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147744Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC50 of 1.0 nM against sonic Hh protein (shh) [1].
CAS Number
1126366-28-6
UNSPSC
12352005
Hazard Statement
H302-H360
Target
Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azd7254.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC(C2=NC=CN2)=C(C)C=C1C)C3=CC=C(OCC4=NC=CC=C4)C=C3
Molecular Formula
C24H22N4O2
Molecular Weight
398.46
Precautions
P264-P270-P280-P330-P405-P501
References & Citations
[1]Yang B, et al. Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5- (1-methylimidazol-4-yl) phenyl]-4- (2-pyridylmethoxy) benzamide (AZD8542) and N-[5- (1H-imidazol-2-yl) -2,4-dimethyl-phenyl]-4- (2- pyridylmethoxy) benzamide (AZD7254) . Bioorg Med Chem. 2020 Jan 15;28 (2) :115227.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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