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SAR-020106

CAT: 0804-HY-100195-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100195-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13.3 nM for human CHK1. SAR-020106 shows excellent selectivity over CHK2. SAR-020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3- to 29-fold in several colon tumor lines and in a p53-dependent fashion. SAR-020106 can enhance antitumor activity with selected anticancer agents[1][2].
CAS Number
1184843-57-9
UNSPSC
12352005
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sar-020106.html
Concentration
10mM
Purity
98.04
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
N#CC1=NC=C(NC2=CC3=C(C=N2)C(Cl)=CC=C3)N=C1O[C@H](C)CN(C)C
Molecular Formula
C19H19ClN6O
Molecular Weight
382.85
References & Citations
[1]Walton MI, et al. The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106. Mol Cancer Ther. 2010;9 (1) :89-100.|[2]Reader JC, et al. Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. J Med Chem. 2011;54 (24) :8328-8342.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1

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Alternative Products

CatalogName
MBS3846893-01SAR-020106
A22371-50SAR-020106 50mg
A22371-25SAR-020106 25mg
A22371-5SAR-020106 5mg
A22371-10SAR-020106 10mg
A22371-1SAR-020106 1mg
A22371-100SAR-020106 100mg

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