SAR-020106

• Description:

  SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC (50) of 13.3 nmol/L on the isolated human enzyme. This compound abrogates an etoposide-induced G (2) arrest with an IC (50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  382.85

• Molecular Formula:

  C19H19ClN6O

• Notes:

  Research use only, not for human use.

• Receptor:

  CHK1

• CAS Number:

  1184843-57-9