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6-Azathymine

CAT: 0804-HY-136559-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136559-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities[1][2][3][4].
CAS Number
932-53-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; DNA/RNA Synthesis; Influenza Virus; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/6-azathymine.html
Concentration
10mM
Purity
99.94
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N1)NN=C(C)C1=O
Molecular Formula
C4H5N3O2
Molecular Weight
127.10
Precautions
H302, H315, H319, H335
References & Citations
[1]N Tamaki, et al. Purification, Characterization and Inhibition of D-3-aminoisobutyrate Aminotransferase From the Rat Liver. Eur J Biochem. 1990 Apr 20;189 (1) :39-45.|[2]W H PRUSOFF, et al. Effect of the Deoxyriboside of 6-azathymine (Azathymidine) on the Biosynthesis of Deoxyribonucleic Acid by Bone Marrow and Neoplastic Cells (In Vitro) . Biochim Biophys Acta. 1956 Apr;20 (1) :209-14.|[3] R A GAITO, et al. Studies on the Metabolism of Thymine and 6-azathymine. Biochem Pharmacol. Apr-May 1962;11:323-36.|[4]B. Gabrielsen, et al. In vitro and in vivo antiviral (RNA) evaluation of orotidine 51-monophosphatedecarboxylase inhibitors and analogues including 6-azauridine-51- (ethylmethoxyalaninyl) phosphate (a 51-monophosphate prodrug) . Antiviral Chemistry & Chemotherapy (1994) 5 (4), 209-220.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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