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DLG4 rabbit pAb

CAT: 0855-ES20428-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20428-01Size:50 µL
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Background
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Description
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
UniProt
P78352
Swiss Prot
P78352
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human DLG4 AA range: 530-610
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:1000-2000 ELISA 1:5000-20000
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cell junction, synapse, postsynaptic density . Cell junction, synapse . Cytoplasm . Cell projection, axon . Cell projection, dendritic spine . Cell projection, dendrite . Cell junction, synapse, presynapse . High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Suppression of neuronal activity induces synaptic accumulation and clustering of DLG4. .
Other Product Names
Disks large homolog 4 (Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90)
Gene ID (Human)
1742

UniProtKB · P78352

Disks large homolog 4

DLG4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P78352
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DLG4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B7Z1S1, G5E939, Q92941, Q9UKK8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCell projectionCytoplasmMembraneSynapse

Disease

Disease variantIntellectual disability

PTM

LipoproteinPalmitatePhosphoproteinUbl conjugation

Domain

RepeatSH3 domain

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