Trk-B

CAT: 0209-103-M196Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-103-M196Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The neurotrophins, including NGF, BDNF, NT3 and NT4/5, constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to and activating two unrelated receptor types: the p75 neurotrophin receptor (p75NTR) and the Trk family of receptor tyrosine kinases. p75NTR is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF16. It binds all neurotrophins with low affinity to transduce cellular signaling pathways that synergize with or antagonize those activated by the Trk receptors. Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF and NT3, TrkB binds BDNF, NT3 and NT4/5, and TrkC only binds NT3. All Trk family proteins share a conserved, complex subdomain organization consisting of a signal peptide, two cysteinerich domains, a cluster of three leucinerich motifs, and two immunoglobulinlike domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain. Natural splice variants of the different Trks, lacking the first cysteinerich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described. At the protein sequence level, human and mouse TrkB show 94% amino acid sequence identity. The proteins also exhibit crossspecies activity. The primary location of TrkB expression is in the central and peripheral nervous systems. Low level TrkB expression has also been observed in a wide variety of tissues outside the nervous system.
Synonyms
Ntrk2; Tkrb; trkB; AI848316; C030027L06Rik
NCBI Gene ID
18212
UniProt
P1529
Accession Number
NP_001020245
Accession Number mRNA
NM_001025074.1
Chromosomal Location
13 B1-B2; 13 36.0 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant Mouse Trk-B extracellular domain
Clone
(#6B10)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

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