Granzyme B

CAT: 0209-M10-117-L100Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-M10-117-L100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Granzyme family serine proteases are stored in the granules of cytotoxic T lymphocytes and natural killer cells. Granzymes contain one S1 protease domain and are synthesized as preproproteins. Granzymes are released toward pathogen infected or transformed target cells during cellular immune reactions. Target cell entry by granzymes is through perforin channels. Granzymes trigger apoptosis by caspase-dependent and -independent mechanisms. There are five granzymes (A, B, G, H and K) in human and many more in mouse and rat.
Synonyms
Gzmb; GZB; CCP1; Ctla1; Ctla-1; AI553453; CCP-1/C11
NCBI Gene ID
14939
UniProt
P10144
Accession Number
NP_004122.2
Accession Number mRNA
NM_004131.4
Chromosomal Location
14 D3; 14 20.5 cM
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
IIGGHEVKPH SRPYMALLSI KDQQPEAICG GFLIREDFVL TAAHCEGSII NVTLGAHNIK EQEKTQQVIP MVKCIPHPDY NPKTFSNDIM LLKLKSKAKR TRAVRPLNLP RRNVNVKPGD VCYVAGWGRM APMGKYSNTL QEVELTVQKD RECESYFKNR YNKTNQICAG DPKTKRASFR GDSGGPLVCK KVAAGIVSYG YKDGSPPRAF TKVSSFLSWI KKTMKSS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to cleave a synthetic chromogentic Granzyme B substrate. The expected specific activity, when using the Ac-IEPD-pNA substrate at 250C, is greater than 750 nM/min per μg of enzyme.
Length
227
Form
Lyophilized
Molecular Weight
28.9 kDa
Host or Source
Insect cells

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