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TREM-1

CAT: 0209-103-M279Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-103-M279Size:50 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TREM1 (Triggering Receptor Expressed on Myeloid cells) is a type I transmembrane protein having a single Iglike domain. It associates with the adapter protein, DAP12, to deliver an activating signal. Several other TREM family members have been reported that are structurally similar but share less than 30% amino acid identity. TREM1 is expressed on blood neutrophils and a subset of monocytes, and expression is upregulated by bacterial LPS. Engagement of TREM1 with a monoclonal antibody leads to expression of IL8, MCP1, and TNFα suggesting that this receptor plays an important role in inflammatory responses. TREM1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with LPS induced shock. Blockade of TREM1 with a TREM1/ Fc fusion protein protected mice against LPS induced shock.
Synonyms
TREM1
NCBI Gene ID
58217
UniProt
Q9JKE2
Accession Number
NP_067381
Accession Number mRNA
NM_021406
Chromosomal Location
17 C; 17
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant mouse extracellular domain of TREM-1
Clone
(#3C66)
Applications
WB, IHC (F)
Purification Method
Protein A/G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

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