TREM-2

• Description:

  TREM2 is a single Ig domain receptor expressed by cells of myeloid lineage. Two closely related transcripts were reported in mouse and designated TREM2a and TREM2b. TREM2 is a pattern recognition receptor that binds anionic ligands. It associates with the adapter protein DAP12 to deliver an activating signal that plays a role in both innate and adaptive immune responses.

• Synonyms:

  Trem2; Trem2a; Trem2b; Trem2c

• NCBI Gene ID:

  83433

• UniProt:

  Q99NH8

• Accession Number:

  NP_112544

• Accession Number mRNA:

  NM_031254

• Chromosomal Location:

  17 C; 17

• Reactivity:

  Anti-Mouse

• Cross Reactivity:

  Mouse

• Target Antigen:

  Recombinant mouse extracellular domain of TREM-2b

• Clone:

  (#5J46)

• Applications:

  WB

• Purification Method:

  Protein A/G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Rat

• Isotype:

  IgG2