TRAIL/Apo2L

• Description:

  TNF-related apoptosis-inducing ligand (TRAIL) is a ligand molecule which induces apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family. In humans, the gene that encodes for TRAIL is located at chromosome 3q26. TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is caspase-8-dependent. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues.

• Synonyms:

  TNFSF10; TL2; APO2L; CD253; TRAIL; Apo-2L

• NCBI Gene ID:

  8743

• UniProt:

  P50591

• Accession Number:

  NP_003801.1

• Accession Number mRNA:

  NM_003810.3

• Chromosomal Location:

  3q26

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant human TRAIL/ApoL2

• Applications:

  ELISA

• Purification Method:

  Protein A chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

• Form:

  Lyophilized from PBS

• Buffer:

  PBS

• Reconstitution:

  Water

• Storage Conditions:

  The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.

• Host or Source:

  Mouse

• Isotype:

  IgG1, kappa