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TRAIL

CAT: 0209-M10-128-L500Size: 500 µgDry Ice: NoHazardous: No
CAT#:0209-M10-128-L500Size:500 µg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic “death domain”, which activates the cell’s apoptotic machinery. Recombinant murine TRAIL is a 174 amino acid polypeptide (20.0 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL protein.
Synonyms
Tnfsf10; TL2; Ly81; Trail; APO-2L; AI448571; A330042I21Rik
NCBI Gene ID
22035
UniProt
P50592
Accession Number
NP_033451.1
Accession Number mRNA
NM_009425
Chromosomal Location
3 A3; 3
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
MRGGRPQKVA AHITGITRRS NSALIPISKD GKTLGQKIES WESSRKGHSF LNHVLFRNGE LVIEQEGLYY IYSQTYFRFQ EAEDASKMVS KDKVRTKQLV QYIYKYTSYP DPIVLMKSAR NSCWSRDAEY GLYSIYQGGL FELKKNDRIF VSVTNEHLMD LDQEASFFGA FLIN
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Assay#1: Determined by the dose-dependent stimulation of MIP-2 production by mouse spleen cells using a concentration range of 10-100 ng/ml. Assay#2: Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells) . The expected ED50 for this effect is 40.0-60.0 ng/ml.
Length
174
Form
Lyophilized
Molecular Weight
20 kDa
Host or Source
E. coli

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