TRAIL/Apo2L, soluble

CAT: 0209-100-301SSize: 10 µgDry Ice: NoHazardous: No
CAT#:0209-100-301SSize:10 µg
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Description
TRAIL/Apo2L is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptor types belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain", which activates the cell's apoptotic response. Recombinant human soluble TRAIL/Apo2L is a 168 amino acid polypeptide (19.6 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL/Apo2L protein.
Synonyms
TNFSF10; TL2; APO2L; CD253; TRAIL; Apo-2L
NCBI Gene ID
8743
UniProt
P50591
Accession Number
NP_003801.1
Accession Number mRNA
NM_003810.3
Chromosomal Location
3q26
Reactivity
Human
Cross Reactivity
Mouse, Human, Bacteria, Chicken
Sequence
MRERGPQRVA AHITGTRGRS NTLSSPNSKN EKALGRKINS WESSRSGHSF LSNLHLRNGE LVIHEKGFYY IYSQTYFRFQ EEIKENTKND KQMVQYIYKY TSYPDPILLM KSARNSCWSK DAEYGLYSIY QGGIFELKEN DRIFVSVTNE HLIDMDHEAS FFGAFLVG
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Assay#1: Determined by its ability to induce apoptotic cell death in TRAIL-sensitive U343MG cells. The expected ED50 for this effect is 1.0-3.0 ng/ml. Assay#2: Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells) . The expected ED50 for this effect is 0.8 - 2.0 ng/ml.
Length
168
Form
Lyophilized
Molecular Weight
19.6 kDa
Host or Source
E. coli

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