TRAIL R-1/DR4, soluble Recombinant Protein

TRAIL R-1/DR4, soluble Recombinant Protein

• Description: TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain, " which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7 kDa protein (215 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.
• Synonyms: TNFRSF10A; DR4; APO2; CD261; TRAILR1; TRAILR-1
• CAS Number: 9000-83-3
• NCBI Gene ID: 8797
• UniProt: O00220
• Accession Number: NP_003835.3
• Accession Number mRNA: NM_003844.3
• Gene Location: 8p21
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: MSGTGAAAAT PSKVWGSSAG RIEPRGGGRG ALPTSMGQHG PSARARAGRA PGPRPAREAS PRLRVHKTFK FVVVGVLLQV VPSSAATIKL HDQSIGTQQW EHSPLGELCP PGSHRSERPG ACNRCTEGVG YTNASQQLFA CLPCTACKSD EEERSPCTTT RNTACQCKPG TFRNDNSAEM CRKCSTGCPR GMVKVKDCTP WSDIECVHKE SGNGHN
• Detection Range: Measured by its ability to inhibit apoptosis in LN-18 cells.  The expected ED50 for this effect is 0.4 -0.5 µg/ml.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 215
• Form: Lyophilized
• Molecular Weight: 22.7 kDa
• Shipping Conditions: Room Temperature