TRAIL/Apo2L, soluble Recombinant Protein
CAT:
209-100-301S
Size:
10 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
TRAIL/Apo2L, soluble Recombinant Protein
- Description: TRAIL/Apo2L is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptor types belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain", which activates the cell's apoptotic response. Recombinant human soluble TRAIL/Apo2L is a 168 amino acid polypeptide (19.6 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL/Apo2L protein.
- Synonyms: TNFSF10; TL2; APO2L; CD253; TRAIL; Apo-2L
- CAS Number: 9000-83-3
- NCBI Gene ID: 8743
- UniProt: P50591
- Accession Number: NP_003801.1
- Accession Number mRNA: NM_003810.3
- Gene Location: 3q26
- Host: E. coli
- Origin Species: Human
- Species Reactivity: Mouse, Human, Bacteria, Chicken
- Sequence: MRERGPQRVA AHITGTRGRS NTLSSPNSKN EKALGRKINS WESSRSGHSF LSNLHLRNGE LVIHEKGFYY IYSQTYFRFQ EEIKENTKND KQMVQYIYKY TSYPDPILLM KSARNSCWSK DAEYGLYSIY QGGIFELKEN DRIFVSVTNE HLIDMDHEAS FFGAFLVG
- Detection Range: Assay#1: Determined by its ability to induce apoptotic cell death in TRAIL-sensitive U343MG cells. The expected ED50 for this effect is 1.0-3.0 ng/ml. Assay#2: Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells). The expected ED50 for this effect is 0.8 - 2.0 ng/ml.
- Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
- Purity: > 98% by SDS-PAGE & HPLC analyses
- Length: 168
- Form: Lyophilized
- Molecular Weight: 19.6 kDa
- Shipping Conditions: Room Temperature