TGF-beta 3 (Animal Free) Recombinant Protein

TGF-beta 3 (Animal Free) Recombinant Protein

• Description: The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown, but its expression pattern suggests a role in the regulation of certain development processes. Recombinant Human TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
• Synonyms: TGFB3; ARVD; TGF-beta3
• CAS Number: 9000-83-3
• NCBI Gene ID: 7043
• UniProt: P10600
• Accession Number: NP_003230
• Accession Number mRNA: NM_003239
• Gene Location: 14q24
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human, Mouse, Rat, Salamander
• Sequence: ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS
• Detection Range: Determined by TGF-β3’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 is ≤ 0.05 ng/ml, corresponding to a specific activity of 2 x 107 units/mg.
• Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
• Length: 112
• Form: Lyophilized
• Molecular Weight: 25 kDa
• Shipping Conditions: Room Temperature