IFN beta (Animal Free) Recombinant Protein

IFN beta (Animal Free) Recombinant Protein

• Description: Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections.  They also affect cell proliferation and modulate immune responses.  Produced by peripheral blood leukocytes and lymphoblastoid cells, IFN-α is an acid-stable molecule that signals through IFN-α/βR, which is also used by IFN-β.  Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens.  IFN-α contains four highly conserved cysteine residues that form two disulfide bonds, one of which is necessary for biological activity.  PeproTech’s Recombinant Human IFN-β is a 20.0 kDa protein containing 166 amino acid residues.
• Synonyms: IFNB1; IFB; IFF; IFNB
• CAS Number: 9000-83-3
• NCBI Gene ID: 3456
• UniProt: P01574
• Accession Number: NP_002167.1
• Accession Number mRNA: NM_002176
• Gene Location: 9p21
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human, Mouse
• Sequence: MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN
• Detection Range: Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.25 ng/ml, corresponding to a specific activity of ≥ 4 x 106 units/mg.
• Endotoxin: < 0.01 ng/ug of protein (< 0.1 EU/ug)
• Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.
• Length: 166
• Form: Lyophilized
• Molecular Weight: 20 kDa
• Shipping Conditions: Room Temperature