Myostatin Recombinant Protein
CAT:
209-100-255
Size:
10 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Myostatin Recombinant Protein
- Description: Myostatin is a TGF-beta family member that acts as an inhibitor of skeletal muscle growth. This muscle-specific cytokine interacts with Activin type I and type II receptors, and suppresses myoblast proliferation by arresting cell-cycle in the G1 phase. Suppression of Myostatin activity facilitates muscle formation and may be useful in reducing and/or preventing adiposity and type-2 diabetes. Myostatin activity can be blocked by the Activin-binding protein Follistatin, and by the propeptide of Myostatin. Recombinant human Myostatin is a 25.0 kDa protein consisting of two identical 109 amino acid polypeptides linked by a single disulfide bond.
- Synonyms: MSTN; GDF8; MSLHP
- CAS Number: 9000-83-3
- NCBI Gene ID: 2660
- UniProt: O14793
- Accession Number: NP_005250.1
- Accession Number mRNA: NM_005259.2
- Gene Location: 2q32.2
- Host: E. coli
- Origin Species: Human
- Species Reactivity: Mouse, Rat, Human
- Sequence: DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS
- Detection Range: Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED50 for this effect is 17.0-25.0 ng/ml.
- Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
- Purity: > 98% by SDS-PAGE & HPLC analyses
- Length: 109
- Form: Lyophilized
- Molecular Weight: 25 kDa
- Shipping Conditions: Room Temperature